THE FOUNDATION
What NAD⁺ actually does
NAD⁺ is a coenzyme, a small helper molecule, present in every cell of every living thing on earth. It holds two jobs at once. The first is energy: NAD⁺ is the shuttle that carries electrons through your mitochondria, the tiny engines that turn food and oxygen into the cellular fuel called ATP. The second is quieter and, for longevity, arguably more interesting: NAD⁺ is the currency that a whole family of repair-and-maintenance enzymes must spend in order to do their work.
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THE BREAKTHROUGH
Why science turned to NMN
The obvious idea, simply swallow NAD⁺ itself, does not work well, because the molecule is large and unstable and struggles to reach the inside of cells intact. So researchers looked one step upstream, to NAD⁺’s precursors: the raw building blocks the body uses to make its own NAD⁺. The most studied of these is NMN, nicotinamide mononucleotide, a compound that sits just a single step away from NAD⁺ on the cellular assembly line.
What do the human trials actually show? It is worth being honest here, because the honesty is more reassuring than the hype. A 2024 systematic review and meta-analysis pooling twelve randomised controlled trials(513 participants) found that oral NMN reliably and significantly raises blood NAD⁺ levels, the one thing it is asked to do, it does. Beyond that, the early human signals are genuinely interesting: in healthy older men, 250 mg a day improved gait speed and grip strength; a 2024 trial in older adults reported faster walking and better sleep quality; amateur athletes saw a dose-dependent rise in aerobic capacity; and middle-aged adults showed improvements in cholesterol, body weight, blood pressure and arterial stiffness.
What the science does not yet claim is just as important. Many of the larger, life-changing outcomes people hope for remain unproven in humans, and the long-term effects of NMN on lifespan and disease are still being actively studied. This is a field that is early, but real, and that distinction is exactly why we built AGELESS the way we did.
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